5,000+ Tech Workers Laid Off This Week. It's Just The Beginning. | E2286

This Week In Startups is made possible by: IM8 Health - https://IM8health.com/TWIST Every - https://Every.io Sentry - https://Sentry.io/TWIST Plaud - https://Plaud.ai/twist Banks don’t want to hand over their data to AI labs. So David Moscatelli built a $250,000 box that runs AI on-prem. He already has 1,600 pre-orders. On today’s episode of TWiST, Jason and Alex sit down with the Go Abacus founder and Yanez's Jose Caldera to unpack how regulated industries are getting AI without the cloud, why Bittensor subnet 54 is incentivizing miners to attack identity systems, and why Cloudflare just laid off 20% of its workforce in the same week it raised guidance. The show closes with Jason explaining what it means to build an AI-first startup, and how workers can derisk their future employment! Guest Links: Go Abacus https://goabacus.co/ Go1 direct link https://goabacus.co/go1 David Moscatelli on LinkedIn https://www.linkedin.com/in/david-edward-18a369243/ Yanez https://www.yanez.ai/ Bittensor Subnet 54 on TAOstats https://taostats.io/subnets/54 Jose Caldera on LinkedIn https://www.linkedin.com/in/josercaldera/ LAUNCH Links: Founder University https://founder.university/ Founder University Japan application portal https://tokyo.launch.co/ News Links: Cloudflare lays off 20% of its staff https://www.cnbc.com/2026/05/07/cloudflare-net-q1-2026-stock-earnings-layoffs.html Coinbase cuts 14% of its staff https://www.reuters.com/business/world-at-work/coinbase-cut-about-14-workforce-2026-05-05/ Block post on how it is rebuilding its company https://block.xyz/inside/from-hierarchy-to-intelligence Block’s earnings, including its raised guidance https://s29.q4cdn.com/628966176/files/doc_financials/2026/q1/Block_Q1-2026-Shareholder-Letter.pdf WHOOP’s new on-demand clinicians https://www.cnbc.com/2026/05/08/whoop-on-demand-clinician-access.html Stripe Atlas’s growth https://x.com/patrickc/status/2050206647793144098/photo/1 Timestamps: 0:00 Introduction: Jason in Brooklyn, Knicks playoffs 1:54 Go Abacus joins: AI infrastructure for regulated industries 2:49 The Go1: 2,000-user on-prem AI appliance 2:49 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off! 6:28 Pricing the Go1: How far does $250,000 go? 6:48 1,600 orders and the hardware delivery challenge 9:38 Sentry - New users can get $240 in free credits when they go to https://sentry.io/twist and use the code TWIST 19:47 Every.io - For all of your incorporation, banking, payroll, benefits, accounting, taxes or other back-office administration needs, visit https://every.io 26:46 Chicago tech scene and in-office culture 29:33 IM8 Health: Start feeling like your best self every day. Go to https://IM8health.com/twist and use the code TWiST to get a free welcome kit, five free travel sachets, and 10% off your order. 34:35 Yanez joins: How to prove personhood and uniqueness 37:56 How biometric capture and bio-keys work 39:29 Agent delegation: proving humans authorized AI agents 43:43 Bittensor Subnet 54 and incentivizing adversarial miners 46:35 Founder University Japan Cohort 2 applications open 48:39 Tech layoffs: Cloudflare cuts 20%, Coinbase cuts 14%, Block raises guidance 1:01:38 Anthropic's $50B round at $900B pre-money 1:03:46 WHOOP adds on-demand clinicians 1:06:06 Federalism, state-level regulation, and AI policy Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp Follow Lon: X: https://x.com/lons Follow Alex: X: https://x.com/alex LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis Check out all our partner offers: https://partners.launch.co/ Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland Check out Jason’s suite of newsletters: https://substack.com/@calacanis Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com

GPT-4正在为你翻译摘要中......

翻译全文