This Startup Wants To Catch Cancer Before It Spreads

1 in 11 babies born in America this year will be screened by a genetic test that didn't exist a decade ago. Biotech startup BillionToOne turned a simple but radical idea—detecting rare fragments of fetal DNA in a mother's blood—into one of the most widely used prenatal tests in the U.S. And they're not stopping there. The same approach could unlock something even bigger: early-stage cancer detection from a blood test, a breakthrough that could one day save millions of lives. In this episode of Hard Tech, YC's Jared Friedman sits down with David Tsao and Oguzhan Atay to hear how they went from half a lab bench to a $4B biotech company—and why they believe this is just the beginning of what their technology can do. Learn more: https://www.billiontoone.com Chapters: 00:00 – Finding One Mutation in Billions 01:00 – Detecting Disease From a Blood Sample 02:10 – From Lab Idea to $4B Company 03:05 – The Breakthrough That Made It Possible 05:15 – Building the First Test From Scratch 07:30 – One Customer and a Sales Crisis 08:55 – Inside the Lab: How It Actually Works 12:10 – Detecting Cancer From Blood 13:50 – The Path to Early Cancer Detection 16:05 – Why Early Cancer Detection Is So Hard Apply to Y Combinator: https://www.ycombinator.com/apply Work at a startup: https://www.ycombinator.com/jobs

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